Growth in Response to Pressure Overload Survival but Not in Cardiac Hypertrophic Plays a Critical Role in Cardiomyocyte Mitogen-Activated Protein Kinase
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چکیده
10.1128/MCB.24.24.10611-10620.2004. 2004, 24(24):10611. DOI: Mol. Cell. Biol. and Kinya Otsu Kurihara, Kenneth R. Chien, Junji Takeda, Masatsugu Hori Satoshi Tatsuhiko Sudo, Kenichi Hongo, Yoichiro Kusakari, Atsuko Nakai, Yasushi Matsumura, Jun-ichi Miyazaki, Yoshihiro Uno, Kazunori Kashiwase, Masayuki Taniike, Toshihiro Takeda, Soh Osuka, Takashi Morita, Gen Kondoh, Shungo Hikoso, Yoshiharu Higuchi, Tetsuya Watanabe, Kazuhiko Nishida, Osamu Yamaguchi, Shinichi Hirotani, Growth in Response to Pressure Overload Survival but Not in Cardiac Hypertrophic Plays a Critical Role in Cardiomyocyte Mitogen-Activated Protein Kinase α p38
منابع مشابه
Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart.
RATIONALE Mitogen-activated protein kinase (MAPK) pathways provide a critical connection between extrinsic and intrinsic signals to cardiac hypertrophy. Extracellular signal-regulated protein kinase (ERK)5, an atypical MAPK is activated in the heart by pressure overload. However, the role of ERK5 plays in regulating hypertrophic growth and hypertrophy-induced apoptosis is not completely underst...
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RATIONALE Apoptosis signal-regulating kinase (ASK)1 is a central upstream kinase in the greater mitogen-activated protein kinase cascade that mediates growth and death decisions in cardiac myocytes in response to diverse pathological stimuli. OBJECTIVE However, the role that ASK1 plays in regulating the cardiac hypertrophic response in vivo remains controversial. METHODS AND RESULTS Here, w...
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BACKGROUND Cardiac hypertrophy is a common response to pressure overload and is associated with increased mortality. Mechanical stress in the heart results in the activation of the small GTPase ras and the Raf-1/MEK/ERK signaling cascade in addition to other signaling pathways. METHODS AND RESULTS In an attempt to determine the requirement for the serine/threonine kinase Raf-1 in the pathogen...
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BACKGROUND Heart failure is the leading cause of death in the United States. By delineating the pathways that regulate cardiomyocyte function, we can better understand the pathogenesis of cardiac disease. Many cardiomyocyte signaling pathways activate protein tyrosine kinases. However, the role of specific protein tyrosine phosphatases (PTPs) in these pathways is unknown. METHODS AND RESULTS ...
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Regulator of G-protein signaling 10 (RGS10) is an important member of the RGS family and produces biological effects in multiple organs. We used a genetic approach to study the role of RGS10 in the regulation of pathological cardiac hypertrophy and found that RGS10 can negatively influence pressure overload-induced cardiac remodeling. RGS10 expression was markedly decreased in failing human hea...
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